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Created page with "== Overview == '''Neurofibromatosis type 1''' (NF1), also known as von Recklinghausen disease, is a genetic disorder characterized by the development of multiple neurofibromas, café-au-lait spots, and other systemic manifestations. NF1 is one of the most common genetic disorders, with an incidence of approximately 1 in 3,000 live births. It is caused by mutations in the NF1 gene, which encodes the protein neurofibromin, a negative regulator of the Ras sign..."