IL15RA
Overview
The IL15RA gene, also known as Interleukin 15 receptor alpha, is a gene that is located on the short (p) arm of chromosome 10 at position 15. This gene encodes a protein that is part of the interleukin receptor family.
Function
The IL15RA gene provides instructions for making a protein that forms part of a receptor complex on the surface of certain types of immune cells. This receptor complex binds to a protein called interleukin 15, which is involved in the development, survival, and activation of natural killer cells and T cells, both of which are types of white blood cells that play a crucial role in the body's immune response.
Gene Structure
The IL15RA gene spans approximately 14 kilobases and consists of eight exons. The gene's promoter region contains several binding sites for transcription factors, which are proteins that control the activity of the gene.
Clinical Significance
Mutations in the IL15RA gene have been associated with various immune disorders. For instance, some studies have suggested a link between variations in this gene and susceptibility to rheumatoid arthritis, a chronic inflammatory disorder affecting the joints. Additionally, research has indicated that the IL15RA gene may play a role in the development of certain types of cancer, such as leukemia and melanoma.
Research
Research on the IL15RA gene is ongoing, with scientists seeking to better understand its function and its role in disease. Studies are also being conducted to explore potential therapeutic applications of targeting the IL15RA gene or its protein product in the treatment of immune disorders and cancer.
