View source for The Role of Epigenetics in Human Disease

== Introduction ==
Epigenetics, a subfield of [[Genetics|genetics]], is the study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself. Epigenetic changes can switch genes on or off and determine which proteins are transcribed. They can be influenced by several factors including age, environment, lifestyle, and disease state. The role of epigenetics in human disease has become an area of intense study. This article will delve into the intricate relationship between epigenetic modifications and the development of various human diseases.

[[Image:Detail-17862.jpg|thumb|center|A microscopic view of a DNA strand with visible epigenetic modifications.|class=only_on_mobile]]
[[Image:Detail-17863.jpg|thumb|center|A microscopic view of a DNA strand with visible epigenetic modifications.|class=only_on_desktop]]

== Epigenetic Mechanisms ==
Epigenetic mechanisms are complex and involve changes in the physical structure of DNA, including DNA methylation, histone modification, and non-coding RNA molecules. These mechanisms play a crucial role in the regulation of gene expression, and their dysregulation can lead to the development of disease.

=== DNA Methylation ===
[[DNA Methylation|DNA methylation]] is a process by which methyl groups are added to the DNA molecule, typically at a cytosine or adenine DNA base. This modification can change the activity of a DNA segment without changing the sequence. When located in a gene promoter, DNA methylation typically acts to repress gene transcription. Aberrant DNA methylation patterns are a hallmark of many types of cancer.

[[Image:Detail-17864.jpg|thumb|center|A close-up view of a DNA molecule with methyl groups attached to it.|class=only_on_mobile]]
[[Image:Detail-17865.jpg|thumb|center|A close-up view of a DNA molecule with methyl groups attached to it.|class=only_on_desktop]]

=== Histone Modification ===
Histones are proteins that help structure DNA into a compact, transportable form. They can be modified by the addition or removal of various types of chemical groups, including acetyl, methyl, and phosphate groups. These [[Histone Modification|histone modifications]] can affect gene expression by altering chromatin structure or recruiting histone modifiers. Dysregulation of histone modification patterns can lead to diseases such as cancer, autoimmune diseases, and neurological disorders.

[[Image:Detail-17866.jpg|thumb|center|Histone proteins with DNA wrapped around them, showing various chemical groups attached to the histones.|class=only_on_mobile]]
[[Image:Detail-17867.jpg|thumb|center|Histone proteins with DNA wrapped around them, showing various chemical groups attached to the histones.|class=only_on_desktop]]

=== Non-Coding RNA ===
Non-coding RNAs (ncRNAs) are RNA molecules that do not code for proteins but have roles in regulating gene expression. Some ncRNAs, such as microRNAs and long non-coding RNAs, have been implicated in the development of diseases such as cancer, cardiovascular disease, and neurological disorders.

[[Image:Detail-17868.jpg|thumb|center|A depiction of non-coding RNA molecules interacting with DNA.|class=only_on_mobile]]
[[Image:Detail-17869.jpg|thumb|center|A depiction of non-coding RNA molecules interacting with DNA.|class=only_on_desktop]]

== Epigenetics and Disease ==
Epigenetic changes can lead to abnormal gene function and malignant cellular transformation. Growing evidence suggests that epigenetic changes play a significant role in the development and progression of disease.

=== Cancer ===
In cancer, genes that control cell growth and division are often epigenetically modified. These modifications can lead to uncontrolled cell proliferation and tumor formation. Both DNA methylation and histone modification play a role in the development of various types of cancer, including lung, breast, and colon cancer.

[[Image:Detail-17870.jpg|thumb|center|A microscopic view of cancer cells dividing uncontrollably.|class=only_on_mobile]]
[[Image:Detail-17871.jpg|thumb|center|A microscopic view of cancer cells dividing uncontrollably.|class=only_on_desktop]]

=== Cardiovascular Disease ===
Epigenetic changes can also contribute to the development of cardiovascular disease. For example, DNA methylation patterns can predict the risk of coronary artery disease. Additionally, histone modifications can influence the development of hypertension, a major risk factor for cardiovascular disease.

<div class='only_on_desktop image-preview'><div class='image-preview-loader'></div></div><div class='only_on_mobile image-preview'><div class='image-preview-loader'></div></div>

=== Neurological Disorders ===
Several neurological disorders, including Alzheimer's disease and Parkinson's disease, have been linked to epigenetic changes. These changes can affect neuronal function and lead to neurodegeneration.

[[Image:Detail-17874.jpg|thumb|center|A depiction of neurons with visible synapses.|class=only_on_mobile]]
[[Image:Detail-17875.jpg|thumb|center|A depiction of neurons with visible synapses.|class=only_on_desktop]]

== Epigenetic Therapies ==
Given the role of epigenetics in disease, therapies that target the epigenetic machinery offer a promising approach to treatment. These therapies, known as epigenetic therapies, work by reversing abnormal epigenetic marks associated with disease.

[[Image:Detail-17876.jpg|thumb|center|A depiction of a DNA molecule with visible epigenetic modifications being targeted by therapy.|class=only_on_mobile]]
[[Image:Detail-17877.jpg|thumb|center|A depiction of a DNA molecule with visible epigenetic modifications being targeted by therapy.|class=only_on_desktop]]

== Conclusion ==
The study of epigenetics has significantly expanded our understanding of the molecular mechanisms underlying human disease. As our knowledge continues to grow, so too does the potential for the development of novel, epigenetic-based therapies.

== See Also ==
* [[Genetic Disorders]]
* [[Molecular Biology]]
* [[Gene Therapy]]

[[Category:Genetics]]
[[Category:Epigenetics]]
[[Category:Human Disease]]
[[Category:random]]