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Human leukocyte antigen: Difference between revisions
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(Created page with "== Introduction == The human leukocyte antigen (HLA) system is a complex set of genes located on chromosome 6 in humans. These genes encode cell-surface antigen-presenting proteins that are essential for the immune system to recognize foreign molecules. The HLA system plays a critical role in the regulation of the immune response, particularly in the context of organ transplantation, autoimmune diseases, and susceptibility to infections. == S...") |
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HLA molecules are heterodimeric proteins composed of an alpha chain and a beta-2 microglobulin (for Class I) or an alpha and beta chain (for Class II). The peptide-binding groove of HLA molecules is highly polymorphic, allowing for the presentation of a diverse array of peptides to T cells. | HLA molecules are heterodimeric proteins composed of an alpha chain and a beta-2 microglobulin (for Class I) or an alpha and beta chain (for Class II). The peptide-binding groove of HLA molecules is highly polymorphic, allowing for the presentation of a diverse array of peptides to T cells. | ||
[[Image:Detail-97613.jpg|thumb|center|High-resolution image of a human leukocyte antigen molecule. The image should show the molecular structure with clear labeling of the alpha chain, beta-2 microglobulin, and peptide-binding groove.|class=only_on_mobile]] | |||
[[Image:Detail-97614.jpg|thumb|center|High-resolution image of a human leukocyte antigen molecule. The image should show the molecular structure with clear labeling of the alpha chain, beta-2 microglobulin, and peptide-binding groove.|class=only_on_desktop]] | |||
== Role in Immune Response == | == Role in Immune Response == | ||