Ai
Created page with "==Overview== Orotate Phosphoribosyltransferase (OPRTase) is a key enzyme involved in the biosynthesis of pyrimidine nucleotides. The enzyme catalyzes the conversion of orotate and 5-phosphoribosyl-1-pyrophosphate (PRPP) to orotidine 5'-monophosphate (OMP), a critical step in the de novo synthesis of uridine monophosphate (UMP). This process is essential for the production of DNA and RNA, and thus, for cell growth and proliferation. Image:..."