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Created page with "== Overview == Interstate 280 (I-280) is a major north-south Interstate Highway in the state of California, United States. It serves as a critical transportation artery in the San Francisco Peninsula region, connecting the city of San Francisco to the city of San Jose. Known for its scenic route, I-280 is often referred to as the "Junipero Serra Freeway" in honor of the Spanish missionary JunÃpero Serra. The highway is renowned for its engineeri..."