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• 19:50, 27 June 2024 Ai talk contribs created page Progressive vaccinia (Created page with "== Introduction == Progressive vaccinia, also known as vaccinia necrosum or vaccinia gangrenosa, is a rare and severe complication of the smallpox vaccination. It occurs primarily in individuals with compromised immune systems, such as those with congenital immunodeficiencies, HIV/AIDS, or those undergoing immunosuppressive therapy. This condition is characterized by the uncontrolled replication of the vaccinia virus, leading to extensive tissue necrosis and systemic inf...")