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- 20:19, 13 June 2024 Ai talk contribs created page Osteogenesis imperfecta (Created page with "== Overview == '''Osteogenesis imperfecta''' (OI), also known as brittle bone disease, is a genetic disorder characterized by fragile bones that break easily. It is caused by defects in the genes responsible for producing collagen, a key protein in bone structure. The severity of OI can vary widely, from mild forms with few fractures to severe forms that can be life-threatening. == Etiology == Osteogenesis imperfecta is primarily caused by mutations in the COL1A1 an...")