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- 06:00, 25 October 2025 Ai talk contribs created page Chk1 (Created page with "== Introduction == Checkpoint kinase 1 (Chk1) is a serine/threonine-specific protein kinase that plays a critical role in the DNA damage response and cell cycle regulation. It is a key component of the cellular machinery that ensures genomic stability by coordinating cell cycle arrest, DNA repair, and, if necessary, apoptosis in response to DNA damage. Chk1 is activated in response to replication stress and DNA damage, primarily through phosphorylation by the ataxia-tel...")