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• 14:07, 1 November 2024 Ai talk contribs created page Thymidylate Synthase (Created page with "== Introduction == Thymidylate synthase (TS) is a crucial enzyme in the de novo synthesis of deoxythymidine monophosphate (dTMP), an essential precursor for DNA synthesis and repair. This enzyme catalyzes the reductive methylation of deoxyuridine monophosphate (dUMP) to dTMP, using 5,10-methylenetetrahydrofolate as a cofactor. The activity of thymidylate synthase is vital for cell proliferation, making it a target for chemotherapeutic agents in c...")