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Created page with "== Overview == Carbamoyl Phosphate Synthetase II (CPS II) is a key enzyme involved in the urea cycle and pyrimidine biosynthesis. This enzyme catalyzes the synthesis of carbamoyl phosphate from bicarbonate, glutamine, and two molecules of ATP. This reaction is the first and rate-limiting step in the de novo synthesis of pyrimidines. Image:Detail-48487.jpg|thumb|center|A close-up view of..."